Adopting a Healthy Lifestyle Can Offset Poor Genetic Factors by 60%

A groundbreaking study published in BMJ Evidence Based Medicine has revealed that regular exercise and a healthy diet can counteract the effects of life-shortening genes. The research, conducted by experts from Zhejiang University School of Medicine in China and the University of Edinburgh, analyzed the health data of 353,742 individuals from the UK Biobank to investigate how lifestyle habits and genetics impact longevity.

The study found that individuals with an unhealthy lifestyle faced a 78% higher risk of premature death, regardless of their genetic predisposition. On the other hand, those who maintained healthy lifestyle habits were able to offset the negative effects of their genes and reduce their risk of early death.

Using a polygenic risk score derived from the LifeGen cohort study, the researchers categorized participants into groups based on their genetic predisposition to long, intermediate, or short lifespan risks. They also assessed participants’ lifestyle habits, including smoking, alcohol consumption, physical activity, body shape, sleep patterns, and diet.

Over an average follow-up period of 12.86 years, 24,239 participants passed away. The researchers discovered that individuals genetically predisposed to a shorter lifespan were 21% more likely to die early than those with a longer life expectancy, regardless of their lifestyle choices. However, individuals with an unfavorable lifestyle were 78% more likely to die prematurely than those with a favorable lifestyle, irrespective of their genetic makeup.

The study highlighted four key factors that contribute to a healthier life: not smoking, engaging in regular physical activity, getting adequate sleep, and following a healthy diet. Despite the study’s limitations, such as its observational nature and the homogeneity of the participants (all of European ancestry), the researchers emphasized the importance of a healthy lifestyle in mitigating the impact of genetic factors on lifespan.

According to the findings, individuals at high genetic risk of a shortened lifespan could potentially extend their life expectancy by nearly 5.5 years at the age of 40 by adopting a healthy lifestyle. The researchers underscored the need for public health initiatives and communication strategies to raise awareness about the importance of healthy living and encourage individuals to make positive lifestyle changes.

In conclusion, the study sheds light on the significant role of lifestyle habits in offsetting genetic risks for a shorter lifespan. By making simple changes to their daily routines, individuals can potentially add years to their lives and improve their overall health and well-being. The researchers hope that their findings will inspire individuals to prioritize their health and make informed choices that promote longevity and vitality.