Hopes for cutting-edge technology to prevent oesophageal cancer

Research is under way to find out if cutting-edge technology can prevent cancer progression in people with Barrett’s esophagus, a condition affecting the food pipe. The research was announced to mark World Barrett’s Esophagus Day today. Barrett’s esophagus can cause esophageal cancer in some individuals.

The recently established Breakthrough Cancer Research AllCaN-Oesophageal Network is working on a treatment that aims to target inflammation. The condition is characterized by a transformation in the cells lining the esophagus due to exposure to acid reflux and various stressors, which can increase the risk of these cells becoming more damaged and possibly turning cancerous.

People with Barrett’s esophagus can progress to dysplasia – abnormal cells – or esophageal cancer. Traditionally, patients with dysplasia undergo procedures such as ablation therapy to remove damaged tissue or abnormal cells. However, this thermal approach needs to be carefully applied to avoid damaging the muscles, and some post-procedure complications can occur.

Professor Jacintha O’Sullivan and her team, in collaboration with Mirai Medical, are examining if treating Barrett’s esophagus patient tissue with electroporation can reduce inflammation and alter immune cell biology. This innovative treatment involves pulses of electricity to target affected cells while preserving healthy tissue, potentially revolutionizing care for individuals with this condition.

Orla Dolan, chief executive of Breakthrough Cancer Research, highlighted the importance of this research, stating that electroporation has shown transformative impact in the treatment of skin cancer. Patient Peter Browne expressed his support for the research, emphasizing the importance of identifying those at risk of progression and finding ways to halt it.